Preferred Label : Liposomal CMTR2 Inhibitor AT-1965;
NCIt definition : A liposomal formulation containing an inhibitor of cap-specific mRNA (nucleoside-2-O-)-methyltransferase
2 (cap-methytransferase 2; CMTR2; MTR2; FTSJD1), with potential immunomodulating and
antineoplastic activities. Upon administration, liposomal CMTR2 inhibitor AT1965 targets,
binds to, and inhibits the activity of CMTR2. This causes the innate immune sensors
to recognize the mRNA as non-self and results in an anti-viral immune response leading
to the activation of B-cells and resulting in a B-cell-mediated immune response against
tumor cells. This induces tumor cell apoptosis and decreases tumor growth. CMTR2,
a key protein in marking newly-synthesized RNA as self, plays a key role in tumor
host immunity evasion. Increased expression of CMTR2 correlates with poor prognosis.
It is overexpressed in a variety of tumor cells.;
Molecule name : AT 1965; AT-1965;
Origin ID : C207271;
concept_is_in_subset
- has_target
