Preferred Label : ALPK1 Agonist PTT-936;
NCIt synonyms : Lymphocyte Alpha-Protein Kinase Agonist PTT-936; Chromosome 4 Kinase Agonist PTT-936; ALPK1 Activator PTT-936; Alpha-Protein Kinase 1 Agonist PTT-936;
NCIt definition : An orally bioavailable innate immune agonist and activator of the cytosolic alpha-protein
kinase 1 (ALPK1) that is an ADP-heptose derived from bacteria, with potential immunomodulating
and antineoplastic activities. Upon oral administration, ALPK1 agonist PTT-936, being
a ADP-heptose, specifically targets and binds to ALPK1, thereby activating the ALPK1-mediated
signal transduction pathway. This initiates the phosphorylation of TRAF-interacting
protein with forkhead-associated domain (TIFA), leading to the activation of pro-inflammatory
nuclear factor kappa-B (NF-kB) signaling, cytokine induction and the activation and
recruitment of immune cells, such as natural killer (NK) cells and T-cells. This leads
to tumor cell eradication and inhibits tumor cell proliferation. ALPK1, a bacterial
pattern recognition receptor (PPR), is involved in bacterial pathogen recognition
and plays a key role in innate immune defenses against bacterial infection. It recognizes
ADP-heptose, a metabolite released during the biosynthesis and degradation of lipopolysaccharides
(LPS), which is present in bacteria but not present in mammalian cells.;
Molecule name : PTT-936; PTT 936;
Origin ID : C207264;
concept_is_in_subset
- has_target
