Preferred Label : Anti-CNTN4 Monoclonal Antibody GENA-104A16;
NCIt synonyms : Anti-contactin-4 Monoclonal Antibody GENA-104A16;
NCIt definition : An affinity-matured humanized monoclonal antibody directed against the inhibitory
immune checkpoint protein contactin 4 (contactin-4; CNTN4), with potential immunomodulating
and antineoplastic activities. Upon administration, anti-CNTN4 monoclonal antibody
GENA-104A16 targets and binds to CNTN4 expressed on cancer cells. This abrogates CNTN4-mediated
immune suppression, decreases regulatory T-cells (Tregs), and may restore and increase
CD4 and CD8 T-cell proliferation and activation and the release of inflammatory
cytokines. This may lead to a cytotoxic T-lymphocyte (CTL)-mediated killing of tumor
cells that overexpress CNTN4. CNTN4 negatively regulates T-cell activity through binding
with amyloid precursor protein (APP) on T-cells. It is overexpressed on a variety
of tumor cell types.;
Molecule name : GENA-104A16; GENA 104A16; BI-1607;
Origin ID : C207233;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
