Carbonic Anhydrase-Related Protein

Preferred Label : Carbonic Anhydrase-Related Protein;

NCIt synonyms : CA VIII; CA8; CA-Related Protein; CA-VIII; Carbonic Anhydrase VIII; Carbonic Anhydrase 8;

NCIt related terms : CARP;

NCIt definition : Carbonic anhydrase-related protein (290 aa, 33 kDa) is encoded by the human CA8 gene. This protein may play a role in bone maintenance and the development of the central nervous system.;

Alternative definition : CDISC: An antigen encoded by the CA8 gene and regulates calcium release and neuron mobility. It can be considered as an autoantigen and is commonly associated with autoimmune paraneoplastic cerebellar degeneration and autoimmune dementia.;

NCIt note : Carbonic anhydrase-related protein is highly homologous to carbonic anhydrase proteins. However, it lacks enzymatic activity due to absence of one of the catalytic zinc coordinating residues. Carbonic anhydrase-related protein has an arginine at amino acid residue 116 instead of the conserved histidine.;

Details

Origin ID

C207232;

OMIM relation
- Carbonic anhydrase VIII [OMIM gene]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- CA8 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]

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