Preferred Label : Transcription Coregulator Gene;
NCIt synonyms : Transcription Coactivator/Corepressor Gene; Transcriptional Coregulator Gene;
NCIt definition : RNA polymerase II transcription of Class II genes involves the TFIID transcription
complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J,
and TFIIH, as well as gene-specific factors that include TAFs, which interact with
regulatory protein activation domains to enhance transcription. A second group of
cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription.
A third group of factors suppress transcription. The combined action of general and
gene-specific regulators encoded by transcription coactivator genes determines appropriate
gene expression. (NCI);
Origin ID : C20710;
UMLS CUI : C1336778;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
