Preferred Label : T-cell Membrane-anchored Tumor-targeted IL-12-modified Tumor Infiltrating Lymphocytes;
NCIt synonyms : Cell Membrane-anchored Tumor-targeted IL12-modified TILs; mbIL-12-expressing TILs; attIL12-TILs;
NCIt definition : A preparation of tumor infiltrating lymphocytes (TILs) engineered to express membrane-bound
interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities.
Upon infusion of the T-cell membrane-anchored tumor-targeted IL-12-modified TILs,
the cells specifically recognize and kill the tumor cells. IL-12 expression activates
the immune system by promoting the secretion of interferon-gamma (IFNg), activating
natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, further
killing tumor cells.;
Origin ID : C207054;
concept_is_in_subset
