Preferred Label : Allogeneic Regulatory T-cells TRX103;
NCIt synonyms : Allogeneic Engineered Tr1 Regulatory T-cells TRX103; Allogeneic TR1 Tregs TRX103; Allogeneic Type 1 Tregs TRX103; Allogeneic Regulatory Type 1 Cells TRX103; Donor-derived Regulatory T-cells TRX103; Allogeneic Tregs TRX103;
NCIt definition : A preparation of off-the-shelf (OTS), allogeneic CD4 cells engineered to mimic regulatory
type 1 (Tr1) cells, with potential immunomodulating activity. Upon infusion of allogeneic
regulatory T-cells TRX103, these cells secrete the immunomodulatory cytokine interleukin-10
(IL-10) and other cytokines upon exposure to donor T-cells, and may additionally stimulate
the production of de novo Tr1 cells. This suppresses immune responses and resets the
immune system. This may ultimately prevent or reduce graft versus host disease (GvHD).
IL-10 plays a key role in controlling inflammation, downregulating immune responses,
and inducing immunological tolerance. IL-10 induces both a long-lasting antigen specific
T-cell anergy and the differentiation of Tr1 cells.;
Molecule name : TRX 103; TRX-103;
NCI Metathesaurus CUI : CL1929132;
Origin ID : C207034;
concept_is_in_subset
