NCIt definition : Sp1 Activation Cofactor Genes encode (at least 9) protein subunits of the CRSP (Cofactor
Required for SP1 activation) complex, which, along with TFIID, is required for efficient
activation of gene transcription by SP1, a transcription factor that recognizes enhancer
sites in target DNA. Many CRSP complex proteins are also components of other multisubunit
complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with
TR and facilitate TR function on DNA templates in conjunction with initiation factors
and cofactors. (NCI);
Semantic type(s)