Preferred Label : STING Agonist PF-07820435;
NCIt definition : An orally bioavailable agonist of the intracellular innate immune adaptor stimulator
of interferon genes protein (STING; transmembrane protein 173; TMEM173), with potential
immunoactivating and antineoplastic activities. Upon oral administration, STING agonist
PF-07820435 targets and binds to STING and activates the STING pathway in immune cells
in the tumor microenvironment (TME). This leads to the production of pro-inflammatory
cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated
antigens (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated
immune response against cancer cells. STING, a transmembrane protein that activates
immune cells in the TME, plays a key role in the activation of the innate immune system.;
Molecule name : PF-07820435; PF 07820435;
NCI Metathesaurus CUI : CL1928807;
Origin ID : C206715;
concept_is_in_subset
- has_target
