Preferred Label : TFIIIB Subunit Gene;
NCIt definition : Human TFIIIB Subunit Genes, BDP1, BRF1, and, BRF2, encode protein subunits of RNA
Polymerase III Transcription Initiation Factor IIIB, required for RNA polymerase III
transcription. Transcription begins with TFIIIC recognition of promoter A and B boxes
and TFIIIA, TFIIIB, and RNA polymerase III binding. 90-kDa BRF1 contains a C-terminal
HMG2-related region and an N-terminal TFII2B-related sequence. 50-kDa BRF2 has a zinc
ribbon domain and a core domain, necessary for complex formation with DNA. Involved
in nucleation of a polymerase III initiation complex, BRF2 does not directly bind
DNA but interacts with TBP, which binds cooperatively to the promoter. TBP, an essential
component of TFIIIB, binds the highly charged C-terminus of BRF1. Highly hydrophilic
BDP1 contains a DNA-ligase A1 ATP-dependent binding site and several potential phosphorylation
sites. (NCI);
Origin ID : C20669;
UMLS CUI : C1336617;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
