Preferred Label : HOX Pathway Mutation;
NCIt synonyms : HOX Family Pathway Mutation; Homeobox Gene Family Pathway Mutation; Homeobox Family Pathway Mutation; HOX Gene Family Pathway Mutation;
NCIt definition : A change in the sequence of one or more genes that are involved in the signaling pathways
that regulate either the expression of homeobox (HOX) family genes or transcription
factor activity of HOX proteins. HOX gene expression is crucial for spatial and temporal
regulation of transcription needed for embryonic development and hematopoiesis; mutations
that dysregulate expression or transcription factor activities of HOX proteins are
associated with oncogenesis.;
NCI Metathesaurus CUI : CL1928839;
Origin ID : C206671;
concept_is_in_subset
