Preferred Label : TFIIIC Subunit Gene;
NCIt definition : RNA polymerases are unable to initiate RNA synthesis in the absence of general transcription
factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA
polymerase. TFIIIC Subunit Genes encode the TFIIIC protein complex that is essential
for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including
5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.
The TFIIIC complex interacts with TFIIIB in the recruitment of RNA polymerase III.
Transcription by RNA polymerase III is enhanced during viral infection by the expression
of immediate early proteins of adenovirus and pseudorabies virus. (from OMIM 604888);
Origin ID : C20663;
UMLS CUI : C1336618;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
