Preferred Label : RNA Polymerase II Subunit Gene;
NCIt synonyms : RNA Polymerase-II Subunit Gene;
NCIt definition : RNA polymerase II subunit genes encode DNA-dependent RNA polymerase II, a complex
multisubunit enzyme that is responsible for the transcription of protein-coding genes.
Ten to 14 subunits encoded by these genes range in size from 220 to 10 kD. The complex
interacts with the promoter regions of genes as well as with a variety of elements
and transcription factors to determine essentially all of the parameters that govern
transcription, e.g., tissue and development specificity, stress response, etc. A fraction
of the large subunit of Pol II (Pol II LS) is ubiquitinated after exposing cells to
UV radiation or cisplatin. (NCI);
Origin ID : C20660;
UMLS CUI : C1335628;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
