Preferred Label : TFIIH Subunit Gene;
NCIt definition : For transcription initiation, the nonphosphorylated RNA polymerase II is recruited
by TFIIF to the DB complex. This complex is recognized by TFIIE, TFIIH, and TFIIJ
to form a transcription-competent complex. Phosphorylation of the C-terminal domain
of the largest subunit of RNA polymerase II controls the transition from transcription
initiation to elongation and TFIIH contains a kinase activity for phosphorylating
this domain. Factors that promote the association of RNA polymerase II with the preinitiation
complex stimulate this activity. TFIIE, which is required for the stable association
of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase.
TFIIH is a multisubunit factor of at least 5 proteins of 92, 62, 43, 40, and 35 kD.
A 52-kD subunit has also been identified as a component of the TFIIH core, along with
p89, p62, p44, and p34. (from OMIM, LocusLink and NCI);
NCIt note : Human TFIIH Subunit Genes include CAK complex genes (CDK7, CCNH, and MAT1) and TFIIH
Core Subunit Genes, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, ERCC2, and ERCC3.;
Origin ID : C20654;
UMLS CUI : C1336616;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
