Preferred Label : TFIIE Subunit Gene;
NCIt definition : TFIIE Subunit Genes encode 2 subunit proteins of 56 kD and 34 kD. TFIIE is a heterotetramer
of 2 alpha and 2 beta subunits, both subunits being required for optimal basal-level
transcription. Both subunits are essential to form a stable preinitiation complex.
High levels of gene transcription by RNA polymerase II depend on high rates of transcription
initiation and reinitiation. Initiation requires recruitment of the complete transcription
machinery to a promoter, a process facilitated by activators and chromatin remodeling
factors. Reinitiation occurs through a different pathway. After initiation, a subset
of the transcription machinery remains at the promoter, forming a platform for assembly
of a second transcription complex as a scaffold for formation of a functional reinitiation
complex. Formation of this scaffold depends on ATP and TFIIH. Some activators and
Mediator may promote high levels of transcription. (from OMIM 189962).;
Origin ID : C20647;
UMLS CUI : C1336613;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
