POLEm Endometrial Carcinoma

Preferred Label : POLEm Endometrial Carcinoma;

NCIt synonyms : POLE-Ultra-Mutated Endometrial Cancer; POLE-Ultramutated Endometrial Cancer; POLE-Ultramutated Endometrial Carcinoma; POLEm Endometrial Cancer; POLE-Ultra-Mutated Endometrial Carcinoma;

NCIt definition : An endometrial carcinoma characterized by mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene that result in an ultra-mutated tumor phenotype.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1928569;

Details

Origin ID

C206277;

Disease excludes abnormal cell
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Metrorrhagia [NCIt concept]
- Postmenopausal Hemorrhage [NCIt concept]
Has associated anatomic sites
- Corpus Uteri [NCIt concept]
- Endometrial Cavity [NCIt concept]
- Female Reproductive System [NCIt concept]
- Genitourinary System [NCIt concept]
- Reproductive System [NCIt concept]
- Uterus [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- POLE Gene Mutation [NCIt concept]
disease_has_normal_cell_origin
- Endometrial Glandular Cell [NCIt concept]
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Endometrium [NCIt concept]
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Corpus Uteri [NCIt concept]
- Endometrial Cavity [NCIt concept]
- Female Reproductive System [NCIt concept]
- Genitourinary System [NCIt concept]
- Uterus [NCIt concept]
disease_mapped_to_gene
- POLE Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- POLE Gene [NCIt concept]
- POLE wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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