Preferred Label : Anti-EGFR/Topoisomerase I Inhibitor Antibody-drug Conjugate HLX42;
NCIt synonyms : Anti-EGFR/TOP1i ADC HLX42; Anti-EGFR ADC HLX42;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal
antibody directed against the tumor-associated antigen (TAA) epidermal growth factor
receptor (EGFR) conjugated, via a cleavable linker, to a topoisomerase I inhibitor
(TOP1i), with potential antineoplastic activity. Upon administration of anti-EGFR/TOP1i
ADC HLX42, the anti-EGFR monoclonal antibody moiety targets and binds to EGFR expressed
on tumor cells. Upon binding and cleavage in the tumor microenvironment (TME), the
TOP1i moiety inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
which results in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of EGFR-expressing tumor cells. HLX42 also induces bystander killing activity. EGFR,
a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor
cell proliferation and tumor vascularization.;
Molecule name : HLX 42; HLX-42;
NCI Metathesaurus CUI : CL1928608;
Origin ID : C206272;
concept_is_in_subset
- has_target
