Preferred Label : Anti-EGFR/CD3 Bispecific Antibody SMET12;
NCIt synonyms : Anti-CD3/Anti-EGFR Bispecific Antibody SMET12; EGFR x CD3 T-cell Engager SMET12; EGFR x CD3 TCE SMET12; Anti-EGFR/Anti-CD3 Bispecific Antibody SMET12; EGFR x CD3 Bispecific Antibody SMET12;
NCIt definition : A bispecific antibody and T-cell engager (TCE) targeting both the tumor-associated
antigen (TAA) human epidermal growth factor receptor (EGFR) and the T-cell surface
antigen CD3, with potential immunostimulating and antineoplastic activities. Upon
administration, anti-EGFR/CD3 bispecific antibody SMET12 binds to both CD3 expressed
on T-cells and EGFR expressed on tumor cells. This crosslinks cytotoxic T-lymphocytes
(CTLs) and EGFR-expressing tumor cells, and activates and redirects CTLs to EGFR-expressing
tumor cells. This leads to CTL-mediated killing of EGFR-expressing tumor cells. EGFR,
a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor
cell proliferation and tumor vascularization.;
Molecule name : SMET-12; SMET 12;
NCI Metathesaurus CUI : CL1928609;
Origin ID : C206271;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
