Preferred Label : Anti-Siglec-10 Monoclonal Antibody ONC-841;
NCIt synonyms : Anti-SIGLEC10 Monoclonal Antibody ONC-841;
NCIt definition : A humanized monoclonal antibody directed against the immune checkpoint molecule sialic
acid-binding immunoglobulin (Ig)-like lectin 10 (Siglec-10; SIGLEC10), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-Siglec-10
monoclonal antibody ONC-841 targets and binds to Siglec-10 expressed on various immune
cells, including tumor-associated macrophages (TAMs) and natural killer (NK) cells,
in the tumor microenvironment (TME). This prevents Siglec-10-mediated signaling, and
activates NK cells, macrophages, and T-cells. This abrogates Siglec-10-mediated inhibition
of phagocytosis of tumor cells and induces antibody-dependent cell-mediated cytotoxicity
(ADCC), thereby killing tumor cells and inhibiting tumor cell growth. Siglec-10, an
inhibitory receptor expressed on a variety of immune cells, plays an important role
in tumor immune invasion through its interaction with the tumor-expressed co-stimulatory
molecule CD24.;
Molecule name : ONC 841; ONC-841;
NCI Metathesaurus CUI : CL1928612;
Origin ID : C206268;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
