Preferred Label : Lutetium Lu 177 XT117;
NCIt synonyms : [177Lu]Lu-XT117; Lu-177-XT117; 177Lu-labeled XT117;
NCIt definition : A radioconjugate composed of XT117, a fibroblast activation protein inhibitor (FAPi),
conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential
antineoplastic activity against FAP-expressing cancer-associated fibroblasts (CAFs).
Upon administration, lutetium Lu 177 XT117 targets and binds to FAP-expressing CAFs.
Upon binding, FAP-expressing CAFs are destroyed by 177Lu through the specific delivery
of beta particle radiation. FAP, a cell surface protein, is overexpressed on CAFs
in the tumor microenvironment (TME) of various cancers.;
NCI Metathesaurus CUI : CL1928602;
Origin ID : C206262;
concept_is_in_subset
- has_target
