Preferred Label : Salmonella enterica serovar Typhi ZH9;
NCIt definition : A formulation containing a live-attenuated strain of the bacterium Salmonella typhi,
with potential immunomodulating and antineoplastic activities. Upon administration
of Salmonella enterica serovar Typhi ZH9, the Salmonella in ZH9 may cause a Salmonella-induced
systemic reprogramming of myeloid cells within the tumor microenvironment (TME). This
enhances the recruitment of innate and adaptive immune cells, including the upregulation
of co-stimulatory and major histocompatibility (MHC) molecules on dendritic cells
(DCs), natural killer (NK) cells, CD4 and CD8 T-cells, monocytes, and macrophages.
This may alleviate immune suppression, restore immune fitness and tissue immunosurveillance
and re-activate an anti-tumor immune response.;
Molecule name : ZH-9; ZH 9; M01ZH 09; M01ZH-09;
NCI Metathesaurus CUI : CL1928595;
Origin ID : C206253;
concept_is_in_subset
