Preferred Label : Pan-RAR Agonist/AP-1 Inhibitor LGD 1550;
NCIt synonyms : LGD 1550;
NCIt related terms : (2E,4E,6E)-7-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic Acid;
NCIt definition : An orally-active synthetic aromatic retinoic acid agent with potential antineoplastic
and chemopreventive activities. LGD 1550 selectively binds to all three retinoic acid
receptors (RAR-alpha, RAR-beta, and RAR-gamma), resulting in alterations in the expression
of genes responsible for cell differentiation and proliferation. This agent also acts
as an inhibitor of activator protein 1 (AP-1), a protein that mediates trophic responses
and malignant transformation. (NCI04);
CAS number : 178600-20-9;
Molecule name : LGD 1550;
Codes from synonyms : 31896;
Origin ID : C2062;
UMLS CUI : C1708619;
Semantic type(s)
- concept_is_in_subset
