Preferred Label : Iodine I 124 hJAA-F11;
NCIt synonyms : Iodine-124 hJAA-F11; Iodine I 124-labeled hJAA-F11; 124I hJAA-F11;
NCIt definition : A radioimmunoconjugate composed of a humanized form of the mouse monoclonal antibody
JAA-F11 (hJAA-F11) directed against the alpha-O-linked galactose disaccharide and
tumor-associated antigen (TAA) Thomsen-Friedenreich (TF) antigen (TF-Ag) labeled with
the radioisotope iodine I 124, with potential imaging activity upon positron-emission
tomography (PET). Upon administration of iodine I 124 hJAA-F11, the antibody moiety
specifically targets and binds to alpha-linked TF-Ag expressed on tumor cells, thereby
allowing for the visualization of TF-Ag-expressing tumors upon PET. This may facilitate
the assessment of the effectiveness of hJAA-F11. In tumor cells, TF-Ag appears as
the disaccharide D-galactose-beta-(1-3)-N-acetyl galactosamine (Gal-beta-(1-3)-GalNAc)
that is specifically alpha linked to a serine or a threonine residue on proteins.
It is overexpressed on a variety of tumor cells and its expression is associated with
tumor cell adhesion, tissue invasion and aggressiveness.;
NCI Metathesaurus CUI : CL1928467;
Origin ID : C206074;
concept_is_in_subset
