Preferred Label : TBP Inhibitor Gene;
NCIt definition : The assembly of transcription complexes at eukaryotic promoters involves a number
of distinct steps, including chromatin remodeling and recruitment of a TATA-binding
protein (TBP)-containing complexes, the RNA polymerase II holoenzyme. Each of these
stages is controlled by positive and negative factors that regulate the interactions
of TBP with promoter DNA. The magnitude by which an activated gene is expressed, might
depend in part on competition between TBP inhibitors and the holoenzyme for access
to the TBP/TATA complex. The first is autorepression, where TBP sequesters its DNA-binding
surface through dimerization. Once TBP is bound to DNA, TAF(II)250 and Mot1 induce
TBP to dissociate, while NC2 and the NOT complex convert the TBP/DNA complex into
an inactive state. TFIIA antagonizes these TBP repressors only in conjunction with
the recruitment of the RNA polymerase II holoenzyme by promoter-bound activators.
(from PMID 10974559);
Origin ID : C20599;
UMLS CUI : C1336595;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
