Preferred Label : Anti-CDH6/Exatecan ADC CUSP06;
NCIt synonyms : Anti-cadherin-6 ADC CUSP06; Anti-CDH6 ADC CUSP06; CDH6-targeting Antibody-drug Conjugate CUSP06;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against the tumor-associated antigen (TAA) cadherin-6 (CDH6; CDH-6; K-cadherin) conjugated,
via a protease cleavable linker, to the camptothecin analog and cytotoxic DNA topoisomerase
I inhibitor exatecan, with potential antineoplastic activity. Upon administration
of anti-CDH6/exatecan ADC CUSP06, the anti-CDH6 antibody moiety targets and binds
to CDH6-expressing tumor cells. Upon uptake and cleavage of the linker by proteases,
exatecan targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable
complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA
replication and induction of apoptosis. This inhibits the proliferation of CDH6-expressing
tumor cells. In addition, this may cause a bystander effect, thereby further killing
CDH6-expressing tumor cells. CDH6, a member of the cadherin family and overexpressed
by a variety of cancers, plays a key role in tumor cell proliferation.;
Molecule name : AMT 707; CUSP 06; AMT-707; CUSP-06;
NCI Metathesaurus CUI : CL1928161;
Origin ID : C205855;
concept_is_in_subset
- has_target
