Preferred Label : IL-2 Fusion Protein PTX-912;
NCIt definition : A fusion protein consisting of the cytokine interleukin-2 (IL-2) fused to an as of
yet not fully elucidated protein, with potential immunopotentiating and antineoplastic
activities. Upon administration, IL-2 fusion protein PTX-912 targets and binds to
IL-2 receptors, and activates IL-2 receptor-mediated signaling in immune cells. This
activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces
expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming
growth factor-beta (TGFb). This leads to T-cell-mediated cytotoxic immune responses
against tumor cells and inhibits tumor cell proliferation.;
Molecule name : PTX 912; PTX-912;
NCI Metathesaurus CUI : CL1928420;
Origin ID : C205741;
chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
