NCIt synonyms : High Mobility Group B Gene Family;
NCIt definition : Human HMGB Family Genes encode abundant DNA-binding and bending HMG-Box Family proteins
(with structure, rather than sequence, specificity) that play an architectural role
in nucleoprotein assembly. They have two homologous DNA-binding HMG-box domains connected
by a short basic linker to an acidic C-terminus that differs in length. Tail length
may be the dominant factor mediating property differences among HMGB proteins and
determines DNA-binding properties of the HMG boxes. The tail is essential for DNA-binding.
(NCI);
Semantic type(s)