Preferred Label : Anti-ENTPD2 Monoclonal Antibody KAZ954;
NCIt synonyms : Anti-ectonucleoside Triphosphate Diphosphohydrolase 2 Monoclonal Antibody KAZ954;
NCIt definition : A monoclonal antibody directed against ectonucleoside triphosphate diphosphohydrolase
2 (ENTPD2), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-ENTPD2 monoclonal antibody KAZ954 targets and binds to ENTPD2 expressed on a
variety of tumor cells and inhibits its hydrolase activity, thereby preventing the
conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP). This leads
to an increased intra-tumoral ATP:ADP ratio, an increase in intra-tumoral monocytes,
natural killer (NK) cells, peripheral CD8 T cells, macrophages, and CD11b dendritic
cells (DCs), and results in a systemic pro-inflammatory response in the tumor microenvironment
(TME). In addition, KAZ954 induces antibody-dependent cellular cytotoxicity (ADCC)
in ENTPD2-overexpressing tumor cells. ENTPD2 catalyzes the hydrolysis of ATP, reduces
the cytotoxic antitumor immune response, enhances the proliferation and polarization
of immunosuppressive cells, and increases neovascularization. It plays a key role
in the creation of an immunosuppressive TME.;
Molecule name : KAZ 954; KAZ-954;
NCI Metathesaurus CUI : CL1928368;
Origin ID : C205683;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
