Preferred Label : Anti-nectin-4/MMAE Antibody-drug Conjugate CRB-701;
NCIt synonyms : Anti-nectin-4 ADC CRB-701; ADC CRB-701; Anti-nectin-4/MMAE ADC CRB-701; Anti-nectin-4/MMAE ADC SYS6002; Anti-nectin-4/MMAE Antibody-drug Conjugate SYS6002;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal
antibody directed against the cell surface adhesion molecule and tumor-associated
antigen (TAA) nectin-4 (PVRL4), site-specifically conjugated, via a cleavable linker,
to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic
activity. Upon administration of anti-nectin-4/MMAE ADC CRB-701, the anti-nectin-4
antibody moiety targets and binds to nectin-4 expressed on tumor cells. Upon binding,
internalization, and linker cleavage, MMAE binds to tubulin and inhibits its polymerization,
which results in G2/M phase arrest and induces apoptosis in nectin-4-expressing tumor
cells. Nectin-4, a TAA belonging to the nectin family, is overexpressed in a variety
of cancers, but has a restricted distribution in normal tissue. CRB-701 may also induce
anti-tumor activity through the induction of antibody-dependent cellular cytotoxicity
(ADCC) and complement-dependent cytotoxicity (CDC) against nectin-4-expressing tumor
cells.;
Molecule name : CRB-701; SYS 6002; SYS-6002; CRB 701;
NCI Metathesaurus CUI : CL1928300;
Origin ID : C205638;
concept_is_in_subset
- has_target
