Preferred Label : Recombinant Oncolytic Adenovirus 5 Encoding Non-secreting Interleukin-12 BioTTT001;
NCIt synonyms : Ad5 Encoding IL-12 BioTTT001; Ad5-TD-nsIL-12; Recombinant Oncolytic Ad5 Encoding nsIL-12 BioTTT001;
NCIt definition : A recombinant oncolytic adenovirus serotype 5 (Ad5) encoding a modified and non-secreting
(ns) form of the human immunostimulating cytokine interleukin-12 (IL-12), with potential
oncolytic, immunostimulating and antineoplastic activities. Upon administration, recombinant
oncolytic Ad5 encoding nsIL-12 BioTTT001 specifically infects and replicates in tumor
cells causing viral-mediated tumor cell lysis. The released virus particles, in turn,
infect and replicate in neighboring tumor cells. Tumor antigens released from the
lysed tumor cells also activate the immune system to induce a tumor-specific cytotoxic
T-lymphocyte (CTL)-mediated immune response, thereby killing nearby non-infected tumor
cells. In addition, nsIL-12 expressed by the adenovirus may activate the immune system
by promoting the activation of natural killer cells (NKs), inducing the secretion
of interferon-gamma (IFN-g) and inducing CTL-mediated immune responses against tumor
cells, which may result in immune-mediated tumor cell death and inhibition of tumor
cell proliferation. The modification of nsIL-12 prevents the secretion of IL-12 from
cells and reduces systemic exposure, thereby decreasing adverse side effects.;
Molecule name : BioTTT 001; BioTTT-001;
NCI Metathesaurus CUI : CL1927630;
Origin ID : C205444;
concept_is_in_subset
