Preferred Label : Oncolytic Vaccinia Virus Expressing Leptin/IL-2 Fusion Protein ASP1012;
NCIt synonyms : Oncolytic Vaccinia Virus ASP1012; Oncolytic VV ASP1012; Oncolytic Virus ASP1012; Oncolytic Vaccinia Virus Expressing Leptin-IL2 Fusion Protein ASP1012; Oncolytic VV Expressing Leptin/IL-2 Fusion Protein ASP1012;
NCIt definition : An oncolytic vaccinia virus (VV) engineered to express a fusion protein comprised
of the metabolic modulator and adipokine leptin and the human cytokine interleukin
(IL)-2, with potential oncolytic, immunostimulating and antineoplastic activities.
Upon administration, oncolytic VV expressing leptin/IL-2 fusion protein ASP1012 specifically
infects and replicates in tumor cells causing viral-mediated tumor cell lysis. The
released virus particles, in turn, infect and replicate in neighboring tumor cells.
Tumor antigens released from the lysed tumor cells also activate the immune system
to induce a tumor-specific cytotoxic T-lymphocyte (CTL)-mediated immune response,
thereby killing nearby non-infected tumor cells. In addition, the leptin/IL-2 fusion
protein is expressed by the oncolytic VV in infected cancer cells. Leptin may modulate
and improve T-cell metabolic function in the tumor microenvironment (TME), and enhance
T-cell-mediated anti-tumor immune responses. IL-2 may further stimulate anti-tumor
immune responses, thereby increasing tumor cell killing and decreasing tumor cell
proliferation.;
Molecule name : VET2 L2; ASP 1012; VET2-L2; ASP-1012;
NCI Metathesaurus CUI : CL1927629;
Origin ID : C205441;
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