Preferred Label : TFIIA Subunit Gene;
NCIt definition : The three subunits of the TFIIA complex (alpha, bet, and gamma) are encoded by the
GTF2A1 and GTF2A2 genes. TFIIA has multiple roles in transcription initiation by RNA
polymerase II. First, the association of TFIIA and TBP stabilizes the TBP-TATA element
interaction. In so doing, TFIIA also stimulates transcription by displacing TBP-associated
repressors and counteracts the ability to inhibit TBP binding to DNA. Second, TFIIA
serves as a cofactor for the activators and coactivators. Third, TFIIA is required
for the isomerization and extension of TFIID-promoter contacts and for stabilizing
interactions between TFIID and initiator sequences. (from PMID 10364255);
Origin ID : C20544;
UMLS CUI : C1336611;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
