Preferred Label : Anti-CEA/Anti-4-1BB Bispecific Antibody LM-24C5;
NCIt synonyms : Anti-CEACAM5/Anti-4-1BB Bispecific Antibody LM-24C5; Anti-CEA/4-1BB Bispecific Antibody LM-24C5; Anti-4-1BB/CEA Bispecific Antibody LM-24C5; CEA x 4-1BB Bispecific Antibody LM-24C5; Anti-CEACAM5/Anti-CD137 Bispecific Antibody LM-24C5;
NCIt definition : A bispecific antibody targeting both the tumor-associated antigen (TAA) carcinoembryonic
antigen-related cell adhesion molecule 5 (CEACAM5; CEA) and the costimulatory receptor
4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with
potential immunostimulating and antineoplastic activities. Upon administration, anti-CEA/anti-4-1BB
bispecific antibody LM-24C5 simultaneously targets and binds to CEA expressed on tumor
cells and 4-1BB expressed on activated T-lymphocytes and natural killer (NK) cells.
This crosslinks CEA-expressing tumor cells and 4-1BB-expressing T-cells and NK cells,
and activates 4-1BB signaling locally in the tumor microenvironment (TME). This results
in cytotoxic T-cell co-stimulation, enhances T-lymphocyte-mediated anti-tumor activity
and leads to cytotoxic T-cell-mediated lysis of CEA-expressing tumor cells. CEA is
overexpressed by a variety of cancer cell types and plays a key role in cell migration,
cell invasion, and cell adhesion. 4-1BB, a surface glycoprotein of the tumor necrosis
factor receptor superfamily, is an inducible costimulatory receptor that plays a key
role in T-cell proliferation, survival and cytolytic activity.;
Molecule name : LM 24C5; LM-24C5;
NCI Metathesaurus CUI : CL1927676;
Origin ID : C205435;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
