Preferred Label : KRAS G12C Inhibitor BBO-8520;
NCIt synonyms : KRAS G12C (ON) Inhibitor BBO-8520; KRAS G12C (ON)/KRAS G12C (OFF) Inhibitor BBO-8520;
NCIt definition : An orally bioavailable, covalent inhibitor of both the active, guanosine triphosphate
(GTP)-bound form and the inactive, guanosine diphosphate (GDP)-bound form of the oncogenic
KRAS substitution mutation G12C, with potential antineoplastic activity. Upon oral
administration, KRAS G12C inhibitor BBO-8520 targets and binds to the switch II pocket
in both the GTP-bound (ON) and GDP-bound (OFF) state conformations of KRAS G12C. This
modifies and inhibits both the GTP-bound (active) and GDP-bound (inactive) forms of
KRAS G12C and prevents KRAS G12C(ON)-mediated signaling, which may inhibit tumor cell
proliferation. KRAS, a member of the RAS family of oncogenes, serves an important
role in cell signaling, division and differentiation. Mutations of KRAS may induce
constitutive signal transduction leading to tumor cell growth, proliferation, invasion,
and metastasis.;
Molecule name : BBO 8520; BBO-8520;
NCI Metathesaurus CUI : CL1927617;
Origin ID : C205358;
concept_is_in_subset
- has_target
