Leukoregulin - CISMeF

Preferred Label : Leukoregulin;

NCIt definition : Secreted by activated natural killer lymphocytes as a 50-kDa glycoprotein lymphokine, Leukoregulin can up regulate the expression of hyaluronan and prostaglandin-endoperoxide H synthase 2 (PTGS2), the inflammatory cyclooxygenase. Leukoregulin shows tumor growth inhibitory activity, enhances membrane permeability, and promotes the uptake of cytotoxic drugs by tumors cells without affecting these processes in normal cells. (NCI);

Details

Origin ID

C20525;

UMLS CUI

C0064839;

Currated CISMeF NLP mapping
- Leukoregulin [OMIM Phenotype]
- leukoregulin [MeSH concept]
- leukoregulin [MeSH Supplementary Concept]
OMIM relation
- Leukoregulin [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- leukoregulin [MeSH concept]
- leukoregulin [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
gene_product_expressed_in_tissue
- T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Lymphokine [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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