Preferred Label : Oncolytic HSV-1 JNJ-87704916;
NCIt synonyms : Oncolytic Virus JNJ-87704916;
NCIt definition : A recombinant oncolytic herpes simplex virus type 1 (HSV-1), with potential oncolytic
and antineoplastic activities. Upon intratumoral administration, oncolytic HSV-1 JNJ-87704916
preferentially infects and replicates in tumor cells causing viral-mediated tumor
cell lysis. The released virus particles, in turn, infect and replicate in neighboring
tumor cells. Tumor antigens released from the lysed tumor cells also activate the
immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte
(CTL) response, thereby killing nearby non-infected tumor cells.;
Molecule name : JNJ 87704916; JNJ-87704916;
NCI Metathesaurus CUI : CL1927220;
Origin ID : C205181;
concept_is_in_subset
