Spongistatin - CISMeF

Preferred Label : Spongistatin;

NCIt synonyms : Spongistatin 1; Altohyrtin A;

NCIt definition : A highly cytotoxic macrocyclic lactone polyether with antitumor activity. Spongistatin, originally isolated from marine Spongia species, binds to the vinca domain of tubulin, thereby interferes with microtubule assembly and results in inhibition of mitosis. This agent does not affect the binding of colchicine to tubulin, but it was a potent inhibitor of the binding of vinblastine and GTP to tubulin.;

CAS number : 148179-94-6;

PubMed : 8232226;

Details

Origin ID

C2051;

UMLS CUI

C0248118;

Currated CISMeF NLP mapping
- spongistatin 1 [MeSH concept]
- spongistatin 1 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- spongistatin 1 [MeSH Supplementary Concept]
- spongistatin 1 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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