Preferred Label : Interferon;
NCIt synonyms : IFN; Human Lymphoblastoid Interferon; Human Leukocyte Interferon; Human Fibroblast Interferon;
NCIt definition : Human interferons have been classified into 3 groups: alpha, beta, and gamma. Both
alpha- and beta-IFNs, previously designated type I, are acid-stable, but they differ
immunologically and in regard to some biologic and physiochemical properties. The
IFNs produced by virus-stimulated leukocytes (leukocyte IFNs) are predominantly of
the alpha type. Those produced by lymphoblastoid cells are about 90% alpha and 10%
beta. Induced fibroblasts produce mainly or exclusively the beta type. The alpha-
and beta-IFNs differ widely in amino acid sequence. The gamma or immune IFNs, which
are produced by T lymphocytes in response to mitogens or to antigens to which they
are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs.
(from OMIM 147570);
Alternative definition : NCI-GLOSS: A biological response modifier (a substance that can improve the body's
natural response to infection and disease). Interferons interfere with the division
of cancer cells and can slow tumor growth. There are several types of interferons,
including interferon-alpha, -beta, and -gamma. These substances are normally produced
by the body. They are also made in the laboratory for use in treating cancer and other
diseases.;
Codes from synonyms : CDR0000045324;
Origin ID : C20493;
UMLS CUI : C0733470;
Semantic type(s)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_plays_role_in_biological_process
- is_chemical_classification_of_gene_product
