Indibulin - CISMeF

Preferred Label : Indibulin;

NCIt synonyms : D 24851; N-(Pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glycoxylamide;

NCIt definition : A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.;

UNII : 80K4H2RB8P;

InChIKey : SOLIIYNRSAWTSQ-UHFFFAOYSA-N;

CAS number : 204205-90-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 204205-90-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : D-24851; D 24851; ZIO-301;

Chemical formula : C22H16ClN3O2;

Details

Origin ID

C2049;

UMLS CUI

C1956330;

Automatic exact mappings (from CISMeF team)
- D 24851 [MeSH concept]
- indibulin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- indibulin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- indibulin [MeSH Supplementary Concept]
- indibulin [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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