Preferred Label : RGD-modified COX-2 Promoter-controlled Conditionally Replicative Adenovirus RGDCRAdCox2F;
NCIt synonyms : RGD-modified COX-2 CRAd RGDCRAdCox2F;
NCIt definition : A conditionally replicative, oncolytic adenovirus type 5 (Ad5), with potential oncolytic
activity. Arg-Gly-Asp (RGD)-modified cyclooxygenase (COX)-2 promoter-controlled conditionally
replicative adenovirus (CRAd) RGDCRAdCox2F has been engineered to replace the original
E1 region with a COX-2 promoter-controlled E1 expression cassette, and to include
RGD modification of the fiber protein. Upon administration, the RGD motif of RGD-modified
COX-2 CRAd RGDCRAdCox2F binds to integrins expressed on tumor cells. This results
in the replication of the oncolytic adenovirus in tumor cells, which induces selective
adenovirus-mediated cytotoxicity in tumor cells and leads to tumor cell lysis. Following
the lysis of the infected cells, the oncolytic virus is released and infects adjacent
cells. This induces further tumor cell oncolysis. The lysis of tumor cells also results
in the release of tumor-associated antigens (TAAs) and inflammatory mediators, which
may activate the immune system to mount an anti-tumor immune response. RGD modification
of the fiber protein enhances the infectivity of the oncolytic virus. COX-2 promoter-controlled
E1 expression regulates the replication of the oncolytic virus as COX-2 is overexpressed
in gastrointestinal malignancies.;
Molecule name : RGDCRAdCox2F;
NCI Metathesaurus CUI : CL1927342;
Origin ID : C204861;
concept_is_in_subset
