Preferred Label : Autologous Total Tumor mRNA Loaded Liposome Vaccine;
NCIt synonyms : Autologous Total Tumor mRNA-nanoparticle Vaccine; Autologous Total Tumor mRNA Loaded DOTAP Liposome Vaccine; Autologous Total Tumor mRNA-NP Vaccine;
NCIt definition : An mRNA-based, personalized cancer vaccine consisting of total tumor RNA (TTRNA) derived
from autologous tumor cells, formulated in DOTAP lipid nanoparticles, with potential
immunostimulatory and antineoplastic activities. Upon administration of the autologous
total tumor mRNA loaded liposome vaccine, the mRNA is taken up, translated and presented
by antigen presenting cells (APCs). The expressed epitopes are then presented via
major histocompatibility complex (MHC) molecules on the surface of the APCs. This
leads to an induction of both cytotoxic T-lymphocyte (CTL)- and memory T-cell-dependent
immune responses that specifically target and destroy the patient's cancer cells that
express these tumor antigens.;
NCI Metathesaurus CUI : CL1926990;
Origin ID : C204794;
UMLS CUI : C5909995;
Semantic type(s)
- concept_is_in_subset
