Preferred Label : Allogeneic Gene-edited CD33-knockout Hematopoietic Stem and Progenitor Cells;
NCIt synonyms : Allogeneic Gene-edited CD33-knockout HSPCs; Allogeneic CD33KO-HSPC; Allogeneic Gene-edited CD33-depleted HSCs;
NCIt definition : A preparation of human allogeneic hematopoietic stem and progenitor cells (HSPCs)
that are ex-vivo gene-edited to remove the cluster of differentiation 33 (CD33) antigen,
that can potentially be used to improve hematopoietic recovery after hematopoietic
cell transplantation (HCT) and CD33-targeting therapy. Upon administration, allogeneic
gene-edited CD33-knockout HSPCs increase and restore the number of HSPCs, which may
prevent or decrease infection and other complications of HCT and chemotherapy-induced
neutropenia (CIN). The removal of CD33 protects the agent from the cytotoxic effects
of CD33-targeted agents administered after HCT.;
NCI Metathesaurus CUI : CL1926999;
Origin ID : C204784;
UMLS CUI : C5909987;
Semantic type(s)
- concept_is_in_subset
