Chemokine - CISMeF

Preferred Label : Chemokine;

NCIt synonyms : Intercrines; Chemotactic Cytokines; Chemokines; Homologous Chemotactic Cytokines; SIS cytokines; Chemotactic Cytokine; Intercrine;

NCIt definition : Chemokines constitute a superfamily of small (8-10 kDa), inducible, secreted, pro-inflammatory cytokines that are involved in a variety of immune and inflammatory responses as well as in viral infection. Chemokines act primarily as chemoattractants and activators of specific types of leukocytes. Some members of this family were initially identified on the basis of their biological activities (e.g., IL-8, GRO), others were discovered using subtractive hybridization (e.g., RANTES) or signal sequence trap (e.g., PBSF/SDF-1)11 cloning strategies. They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system.;

Details

Origin ID

C20466;

UMLS CUI

C0282554;

Automatic exact mappings (from CISMeF team)
- chemokine [COVID-19 Thesaurus concept]
- chemokine [Blood Transfusion thesaurus concept]
- chemokines, c [MeSH Descriptor]
- chemokines, cc [MeSH Descriptor]
Biochemical function of gene products
- Macrophage Inflammatory Protein [NCIt concept]
Currated CISMeF NLP mapping
- Chemokine [FMA entity]
- chemokines [MeSH Descriptor]
- chemokines [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Chemokine [FMA entity]
- chemokines [MeSH concept]
- chemokines [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]

Keyword's position in hierarchy(ies) :

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