PRKAR1A Gene Inactivation

Preferred Label : PRKAR1A Gene Inactivation;

NCIt synonyms : PRKAR1A Loss of Function Gene Mutation; PRKAR1A Loss of Function Mutation; Inactivating Protein Kinase cAMP-Dependent Type I Regulatory Subunit Alpha Gene Mutation; Inactivating PRKAR1 Gene Mutation; Inactivating PKR1 Gene Mutation; Loss of Function PRKAR1A Mutation; PRKAR1A Inactivating Mutation; PRKAR1A Inactivating Gene Mutation; Loss of Function PRKAR1A Gene Mutation; Inactivating TSE1 Gene Mutation;

NCIt definition : A change in the nucleotide sequence of the PRKAR1A gene that inhibits expression or results in the translation of either low-activity or inactive forms of cAMP-dependent protein kinase type I-alpha regulatory subunit protein, which leads to deregulation of protein kinase A-mediated signaling pathways.;

NCI Metathesaurus CUI : CL1926611;

Details

Origin ID

C204572;

UMLS CUI

C5909821;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
is_molecular_abnormality_of_disease
- PRKAR1A-Inactivated Pigmented Epithelioid Melanocytoma [NCIt concept]
molecular_abnormality_involves_gene
- PRKAR1A Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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