WNT-Activated Deep Penetrating/Plexiform Melanocytoma (Nevus)

Preferred Label : WNT-Activated Deep Penetrating/Plexiform Melanocytoma (Nevus);

NCIt definition : A benign melanocytic neoplasm composed of spindle and/or epithelioid melanocytes and melanophages. It is caused by the combined activation of the WNT signaling and MAP-kinase pathways. It occurs in the head and neck region, trunk, extremities, and conjunctiva. It presents with well-circumscribed, darkly pigmented papules. The neoplastic melanocytes form wedge-shaped, fascicular, or plexiform patterns. Lesions with a wedge-shaped pattern extend into the deep reticular dermis. In plexiform spindle cell lesions, the neoplastic melanocytes proliferate in the upper dermis. A junctional component is present in the majority of cases. It rarely progresses to melanoma.;

Neoplastic status : Benign;

NCI Metathesaurus CUI : CL1926607;

Details

Origin ID

C204514;

UMLS CUI

C5909796;

Disease may have findings
- HMB-45-Positive Neoplastic Cells Present [NCIt concept]
- S-100-Positive Neoplastic Cells Present [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Melanocyte [NCIt concept]
disease_has_finding
- Darkly Pigmented Melanophages Present [NCIt concept]
- MAPK Pathway Activated [NCIt concept]
- WNT Pathway Activated [NCIt concept]
disease_has_normal_cell_origin
- Melanocyte [NCIt concept]

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