NCIt definition : An inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with
potential antineoplastic activity. Upon administration, EGFR mutant-selective inhibitor
WZ4002 specifically targets, binds to and inhibits EGFR T790M, which prevents EGFR
T790M mutant-mediated signaling and leads to cell death in EGFR T790M mutant-expressing
tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays
a key role in tumor cell proliferation and tumor vascularization.;
Semantic type(s)