Preferred Label : Therapeutic Bacterial Strain CJRB-101;
NCIt synonyms : Live Biotherapeutic Product CJRB-101; Bacterial Strain Formulation CJRB-101; Live Bacterial Strain CJRB-101;
NCIt definition : A live bacterial strain, with potential immunostimulating and antineoplastic activities.
Upon administration of the therapeutic bacterial strain CJRB-101, the bacteria activates
M1 macrophage and induces repolarization of M2 macrophages. This increases C-X-C motif
chemokine 9 (CXCL9) and 10 (CXCL10)-expressing M1 macrophages and induces a shift
from M2 to M1 macrophage dominance in the tumor microenvironment (TME). This stimulates
the recruitment of other immune cells, increases the population of antigen-presenting
specialized dendritic cells (DCs) and activates cytotoxic CD8 T-cells in the TME.
This may enhance anti-tumor immune responses, specifically a cytotoxic T-lymphocyte
(CTL)-mediated killing of tumor cells, and may eradicate tumor cells.;
Molecule name : CJRB-101; CJRB 101;
NCI Metathesaurus CUI : CL1926563;
Origin ID : C204463;
UMLS CUI : C5908048;
Semantic type(s)
- concept_is_in_subset
