Insulin-Like Growth Factor

Preferred Label : Insulin-Like Growth Factor;

NCIt synonyms : Somatomedin;

NCIt related terms : IGF;

NCIt definition : Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential autocrine ligands) involved in mediation of growth hormone action, stimulation of insulin action, and growth and development. The three main somatomedins are Somatomedin C (IGF1), Somatomedin A (IGF2), and Somatomedin B. Single chain IGFs I and II share about 47% amino acid homology with insulin (INS) and 31% with relaxin.;

Alternative definition : NCI-GLOSS: A protein made by the body that stimulates the growth of many types of cells. IGF is similar to insulin (a hormone made in the pancreas). There are two forms of IGF called IGF-1 and IGF-2. Higher than normal levels of IGF-1 may increase the risk of several types of cancer. IGF is a type of growth factor and a type of cytokine.;

Codes from synonyms : CDR0000653121; CDR0000653119; CDR0000653120;

Details

Origin ID

C20442;

UMLS CUI

C0037657;

Automatic exact mappings (from CISMeF team)
- Insulin-like growth factor II [OMIM gene]
- Insulin-like growth factor-II [LOINC component]
- Somatomedin A (substance) [SNOMED CT concept]
- insulin like growth factor 1 [ORDO Gene]
- insulin like growth factor 2 [ORDO Gene]
- insulin like growth factor 2 [HGNC gene]
- insulin-like growth factor i [MeSH Descriptor]
- insulin-like growth factor ii [MeSH Descriptor]
- insulin-like growth factor receptor binding [GO term]
- somatomedin a [SNOMED Notion]
- somatomedin c [SNOMED Notion]
Currated CISMeF NLP mapping
- Insulin-Like growth factor [OBSOLETE LOINC component]
- Insulin-like growth factor [LOINC component]
- Insulin-like growth factor [MedDRA Preferred Term]
- Somatomedins [LOINC component]
- somatomedin, nos [SNOMED Notion]
- somatomedins [MeSH Descriptor]
- somatomedins [MeSH concept]
False automatic mappings
- Somatomedin (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
UMLS correspondences (same concept)
- Insulin-like growth factor [LOINC component]
- Product containing somatomedin (medicinal product) [SNOMED CT concept]
- Somatomedin (substance) [SNOMED CT concept]
- Somatomedins [LOINC component]
- somatomedin preparation [SNOMED Notion]
- somatomedin, nos [SNOMED Notion]
- somatomedins [MeSH concept]
- somatomedins [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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