Preferred Label : Anti-PTK7/MMAE ADC PRO1107;
NCIt synonyms : ADC PRO1107; Antibody-drug Conjugate PRO1107; Anti-PTK7-LD343 ADC PRO1107;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody against
human inactive tyrosine-protein kinase 7 (protein tyrosine kinase 7; PTK7) linked
to LD343, which is comprised of a protease-cleavable hydrophilic linker conjugated
to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with
potential antineoplastic activity. Upon administration of anti-PTK7/MMAE ADC PRO1107,
the anti-PTK7 antibody moiety targets and binds to PTK7 expressed on tumor cells.
Upon binding, internalization and cleavage, MMAE is released and binds to tubulin,
and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest
and apoptosis in PTK7-expressing tumor cells. In addition, this may cause a bystander
effect, thereby further killing PTK7-expressing tumor cells. PTK7, a tumor-associated
antigen (TAA), is overexpressed on a variety of cancer cells with limited expression
in normal tissues. It is an integral player in cancer cell stemness and tumor progression.
The highly hydrophilic stable, cleavable linker is used to mask the hydrophobicity
of conjugated MMAE.;
Molecule name : PRO 1107; PRO-1107;
NCI Metathesaurus CUI : CL1926868;
Origin ID : C204350;
UMLS CUI : C5908047;
Semantic type(s)
- concept_is_in_subset
- has_target
