Preferred Label : Anti-EphA5/MMAE Antibody-drug Conjugate MBRC-101;
NCIt synonyms : Anti-EphA5/MMAE ADC MBRC-101; Anti-EphA5 ADC MBRC-101;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody against the tyrosine kinase receptor ephrin type-A receptor 5
(EPH receptor A5; EphA5) and conjugated, via a protease-cleavable linker, to the auristatin
derivative and microtubule disrupting agent monomethyl auristatin E (MMAE), with potential
antineoplastic activity. Upon administration of anti-EphA5/MMAE ADC MBRC-101, the
monoclonal antibody moiety targets and binds to EphA5 expressed on tumor cells. Upon
binding, internalization, and proteolytic cleavage, MMAE is released. MMAE binds to
tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor
cell apoptosis. This induces cell death in EphA5-expressing cancer cells. EphA5, a
member of the ephrin family of receptor tyrosine kinases (RTKs) involved in axonal
guidance during embryonic development, is overexpressed by a variety of cancer cell
types.;
Molecule name : MBRC 101; MBRC-101;
NCI Metathesaurus CUI : CL1926869;
Origin ID : C204349;
UMLS CUI : C5908046;
Semantic type(s)
- concept_is_in_subset
- has_target
